PhysioLogic Devices

A revolutionary solution – fully automated, implantable insulin delivery

Portal Diabetes, Inc. is developing the ThinPump™: First fully automated insulin delivery system.
No more carb counting, no more meal announcements, no more sleep interruption.
Clear markets need to reduce management burden thereby improving outcomes.
An open-loop implantable delivery system was developed by this founding team
Closed-loop feasibility is made possible by available CGMs

Why PhysioLogic Devices?

Diabetes is an enormous and growing market lacking an adequate solution.

An implantable artificial pancreas (AP) will functionally cure diabetes.

PhysioLogic’s Plan to Develop the first fully automated insulin delivery device.

Patients, providers, and payers will each greatly benefit from an Implantable AP.

The PhysioLogic team is unique, having previously built all the components of an Implantable AP.

Learn more

About us

PhysioLogic Devices: The ThinPump Artificial Pancreas

Founded by a person who led the engineering development of four different implantable pumps, Pete Lord, PDI is rooted in experience and a patient-driven focus. Leveraging the combined technical and operations talent of Pete's team and recent technology improvements enabling a closed-loop system, Stacy Chambliss brings experience from founding through FDA approval of other class III implantable devices. PDI is uniquely capable of its challenge and privilege in bringing and safe and effective automated implantable pump to patients with type 1 diabetes.

The Challenge

Diabetes | The Elusive Balancing Act

Patients are overwhelmed

24/7 titration with subcutaneous insulin is required with unpredictable outcomes.
Skin site management; infections, tape allergies
Pump Maintenance
Refrigeration of insulin
Purchasing insulin and disposable supplies
Insurance

Why do 80% of T1D patients fail?

80% of patients fail to achieve the control required to prevent chronic complications, blindness, amputations, and kidney failure
Why is glycemic control worsening?
Why is nothing changing?
Management is too burdensome

The ThinPump will make management of diabetes effortless

Insulin is not delivered to the normal physiologic site.
‍It’s time for a new approach!

Technology

The Technology

SOLUTION | ThinPump™ Artificial Pancreas

An implantable pump delivers insulin to the intraperitoneal space

ThinPump™ AP | fully automated

A fully autonomous insulin delivery system. A functional cure for diabetes.

Rapid uptake of intraperitoneal insulin enables a basic control algorithm to fully automate insulin delivery.

Compatible continuous glucose sensor that transmits data to the artificial pancreas.

Updates to the fully automated system may be made post-implantation.

ThinPump™ | Lorem Ipsum Dolor

Insulin is refilled in the clinic every 3 months
The device is replaced about every 7 years when a new battery is needed
Communication with the device is achieved through bluetooth telemetry involving a secure link
The pump is similar in size to a hockey puck and is placed under the skin in the abdomen during a brief, outpatient procedure

Intraperitoneal Insulin Delivery

Getting it to the Right Place

Intraperitoneal insulin is delivered to the liver just as it would from a normal pancreas. Restores the Pancreas-Liver partnership.

Intraperitoneal insulin kinetics are 2x faster than subcutaneous

Faster “on” means less mealtime hyperglycemia
Faster “off” means less hypoglycemia
Decreased tissue insulin means reduced glycemic swings
Normalizes lipids, growth factor, and testosterone levels.

Controls Blood Sugar Level Continuously

Fully automated: a functional cure for diabetes.

90%+ time in range is achievable without user input: no more carb counting, no more meal or activity announcements, and no more corrections

Time-in-range (a key diabetes metric): 96% to 99% is possible with no user input.

The Platform

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